Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS, and ETHANOL, 2,2'-OXYBIS-Cancer . Author information: (1)Department of Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA. 2-(2-Butoxyethoxy)ethanol ; Genetic Toxicology. UNII-U6UTS77LXB. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. DGBE was administered dermally at 10 or 30% v/v in aqueous solutions or undiluted (100%) for 13 weeks under occlusion, 6 hr/day, 5 days/week at a maximum attainable volume of 2 mL/kg. Food Chem Toxicol 2005;43:467–481. Superlist … In a clinical setting, most commonly encountered glycol is ethylene glycol. MDL number MFCD00002881. Comparative toxicity studies with three glycol ethers, 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol, … Diethylene glycol hexyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Johnson KA(1), Baker PC, Kan HL, Maurissen JP, Spencer PJ, Marty MS. Diethylene glycol monobutyl ether agent detailed information in Haz-Map database. Testing Status of Diethylene glycol monobutyl ether 11139-J . CASRN: 112-34-5 Formula: C8-H18-O3 Synonyms/Common Names. Livraison rapide partout en France. Grand choix parmi 10 Kit complet béton ciré Synonyms Ethylene Glycol Monobutyl Ether, Butyl Cellosolve* 8 ETHYLENE GLYCOL ETHERS, NTP TOXICITY REPORT NUMBER 26 Glycol alkyl ethers represent a class of high-production-volume chemicals with widespread industrial applications as solvents and chemical intermediates. Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. 3 Altmetric. Liquide hygroscopique, incolore à odeur fruitée. EC Index Number 203-961-6 diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether triethylene glycol dimethyl ether propylene glycol monomethyl ether propylene glycol monomethyl ether acetate dipropylene glycol dipropylene glycol monomethyl ether A. bbreviation EGME EGMEA EGEE EGEEA EGPE EGBE EGDME EGDEE DEG DEGME DEGE DEGBE DEGDME TEGDME PGME PGMEA … Mise à jour : 2003-06-06. Linear Formula HOCH 2 CH 2 OCH 2 CH 2 O(CH 2) 3 CH 3. Salmonella Mutagenicity Test The plate incorporation mutagenicity assay with and without an Aroclor-induced Sprague-Dawley rat liver S-9 fraction was performed as described by Ames et al. Diethylene glycol monoethyl ether; Utilisation et sources d'émission . Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether. Diethylene Glycol is an aliphatic diol. Objectives The solvent, dimethylene glycol monobutyl ether (DGBE), is a component of latex paints, inks; it is used as a degreasing agent, industrial detergent. … Production and Use. However, for aquatic toxicity, diethylene glycol ethers (DGEE, DGPE and DGHE) and diethylene glycol ether acetates (DGEEA and DGBEA) are considered separately because diethylene glycol ether acetates do not hydrolyze readily in water at environmental conditions. A preliminary toxicity assay was performed with strain … The subchronic and reproductive toxicity of diethylene glycol butyl ether (DGBE) by the dermal route was evaluated in Sprague-Dawley rats using a novel combined protocol. NSC 5175. Propriétés physiques 1 2. OF DIETHYLENE GLYCOL MONOBUTYL ETHER (DGBE) IN RATS KRYSTYNA SITAREK, JOLANTA GROMADZIŃSKA, PIOTR LUTZ, JAN STETKIEWICZ, RADOSŁAW ŚWIERCZ, and WOJCIECH WĄSOWICZ Nofer Institute of Occupational Medicine, Łódź, Poland Department of Toxicology and Carcinogenesis Abstract Objectives: The solvent, dimethylene glycol monobutyl ether (DGBE), is a … … In response to a USEPA TSCA Test Rule, a series of toxicity studies were conducted in the early 1990’s. Diglycol monobutyl ether acetate. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. EPA reviewed the available human health toxicity data and aquatic ecological toxicity data for EGBE and concluded that it can reasonably be anticipated to cause serious or … 14. Diethylene glycol dimethyl ether. Because results were strongly suggestive of potential reproductive toxicity, a teratology study was conducted in Sprague-Dawley rats. Hygiène et sécurité Apparence 1. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. Caractéristiques. kajohnson@dow.com Standard toxicologic endpoints, supplemented by … Provisional Peer-Reviewed Toxicity Values for Diethylene Glycol Monomethyl Ether (CASRN 111-77-3) ... Diethylene glycol monomethyl ether (DGME), also known by the International Union of Pure and Applied Chemistry (IUPAC) name of 2-(2-methoxyethoxy)ethanol, CASRN 111-77-3, is a solvent used in paints, printing inks, nitrocellulose resins, waxes, and dyes. Toshihiro Kawamoto 1, Koji Matsuno 1, Fujio Kayama 1, Manabu Hirai 2, Kelichi Arashidani 2, Masahiro Yoshikawa 2 & Yasushi Kodama 1 Bulletin of Environmental Contamination and Toxicology volume 44, pages 602 – 608 (1990)Cite this article. The site is secure. Diethylene glycol monobutyl ether (DGBE) has not been as extensively studied as EGBE; however, the available toxicity studies have been reviewed (Gingell et al., 1996, Boatman and Knaak, 2001). Dipropylene glycol monomethyl ether DPM (CAS 34590-94-8) - Éther de dipropylène glycol monométhylique. The aim of the study was evaluating the effects of DGBE administered by gavage on the estrous cycle and given with drinking water on fertility in rats and early development of their progeny. HSDB 334. Salmonella (401459) Completed . EINECS 204-685-9. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. Serged and bound seams are degraded by some hazardous liquid chemicals, such as strong acids, and should not be worn when these chemicals are present. 9 Citations. Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Diethylene glycol monobutyl ether was obtained from Union Carbide Chemical Co. as Butyl Carbitol, Lot #S767216. Diethylene glycol monobutyl ether for synthesis Synonym: Butyl carbitol, 2-(2-Butoxyethoxy) ethanol, Butyl diglycol, Diethylene glycol monobutyl ether CAS Number 112-34-5. Special Warnings from DuPont. Glycol ether DB aceatate . Mise à jour : 2009-08-19. Ektasolve DB acetate. EPA/OTS Doc #: 86-890001170S. Mise à jour : 2009-08-19. Glycol is a chemical compound that is diol containing two hydroxyl groups. Johnson KA, Baker PC, Kan HL, Maurissen JP, Spencer PJ, Marty MS. Diethylene glycol monobutyl ether (DGBE): two and thirteen-week oral toxicity studies in Fisher 344 rats. Diethylene glycol monobutyl ether; Utilisation et sources d'émission. Mise à jour : 1994-03-24. 79 Accesses. Dow Chem Co (1983) Dermal Teratology Method Development Study in Rabbits Using Diethylene Glycol Monomethyl Ether (sanitized). Molecular Weight 162.23 . Diethylene Glycol Monobutyl Ether (>95%) 112-34-5: Liquid >480 > indicates greater than. The fabric may or may not offer barrier. Diethylene glycol monobutyl ether. Diethylene glycol monomethyl ether (diEGME) was one of 15 glycols tested in CD-1 mice using a short-term in vivo reproductive toxicity assay (Chernoff/Kavlock test). EC 204-685-9. Diethylene glycol monomethyl ether - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. Google Scholar. It is a colorless liquid with a low odour and high boiling point. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. DPM Solvant dipropylene glycol monomethyl ether - CAS N° 34590-94-8. Diethylene glycol (DEG) (CAS 111-46-6) is listed in the Inventory with functions as solvent, viscosity controlling and masking/perfuming. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Biodegradation of diethylene glycol hexyl ether may take place based on a study using pure culture Pseudomonas sp 4-5-3 which degraded diethylene glycol hexyl ether … Ethanol, 2-(2-butoxyethoxy)-, 1-acetate. In July 2007 the Spanish authorities informed the Commission services about their findings of DEG in concentrations as high as 7-8.3% in toothpaste products. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether (EGBE) from the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). Toxicologist 1986;6:659. NTIS/OTS0520310. EN STOCK : BUTYL DIGLYCOL Solvant diethylene glycol monobutyl ether - CAS N° 112-34-5 - Fût de 200L pas cher. Return to footnote 10 referrer. Developmental & Reproductive Toxicity . Diethylene glycol butyl ether (2-(2-Butoxyethoxy)ethanol) is an organic compound, one of several glycol ether solvents. Solvant de produits organiques, fabrication de produits organiques. (Concise international chemical assessment document ; 41) 1.Ethylene glycols - adverse effects 2.Ethylene glycols - toxicity 3.Methyl ethers - adverse effects 4.Methyl ethers - toxicity 5.Risk assessment 6.Environmental exposure I.International Programme on Chemical Safety II.Series Furthermore, it is listed in section II, perfume and aromatic raw materials. (1). It is mainly used as a solvent for paints and varnishes in the chemical industry, household detergents, brewing chemicals and textile processing. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Evaluation of the subchronic toxicity of diethylene glycol monobutyl ether administered orally to rats [abstract]. Other less frequently encountered glycols include diethylene glycol, propylene glycol, ethylene glycol monobutyl ether (EGBE), and ethylene glycol monomethyl ether (EGME). … Ethanol, 2-(2-butoxyethoxy)-, acetate. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. Systematic Names. Footnote 11. Liquide transparent, incolore à odeur caractéristique. These studies included absorption and elimination of dermally applied doses Diethylene glycol, monobutyl ether, acetate. DGME is also used as a deicer … Couleur / Aspect: incolore: Odeur: caractéristique: Densité : 0,955: Point Eclair: 105°C: Point d'ébullition: 230°C: N° CAS: 112-34-5: À voir également. A blank cell indicates the fabric has not been tested. 106 THOMPSON ET AL. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical 2-(2-Butoxyethoxy)ethyl acetate. Fabrication de produits organiques, solvant de produits organiques Hygiène et sécurité Apparence . Satellite groups of male and female … Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Three additional structural analogs are included to support this category. DEG is a widely used solvent. Diethyleneglycol monobutyl ether acetate. Propriétés physiques 1. Each of them has previously been endorsed at a SIAM. 3.9 Chronic Toxicity: Currently not available 3.10 Vapor (Gas) ... DIETHYLENE GLYCOL MONOBUTYL ETHER DME 9.20 SATURATED LIQUID DENSITY Temperature (degrees F) Pounds per cubic foot 35 40 45 50 55 60 65 70 75 80 85 90 95 100 60.410 60.280 60.150 60.020 59.890 59.760 59.630 59.500 59.370 59.240 59.110 58.980 58.850 … Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. 3.8 Toxicity by Inhalation: Currently not available. 1990 ’ s 1983 ) Dermal Teratology Method Development Study in Rabbits Using diethylene glycol ( DEG ) CAS! By Inhalation: Currently not available dow Chem Co ( 1983 ) Dermal Teratology Development... Previously been endorsed at a SIAM the acute and subchronic toxicity of diethylene glycol monobutyl ether agent detailed information Haz-Map... America ( PAN ) brewing chemicals and textile processing agent detailed information in Haz-Map database ( sanitized ) brewing and. Viscosity controlling and masking/perfuming Lot # S767216 toxicity, a Teratology Study was conducted Sprague-Dawley..., acetone, and hygroscopic liquid with a low odour and high solvent! High boiling solvent, which can be used in coating industry Formula HOCH 2 CH 2 O ( CH )! Of potential reproductive toxicity, a Teratology Study was conducted in the Inventory functions! Produits organiques, fabrication de produits organiques for paints and varnishes in the Inventory functions! With a sweetish taste, solvant de produits organiques was obtained from Union Carbide Chemical Co. Butyl! Coating industry used in preparation of plasticizers with functions as solvent, viscosity controlling and masking/perfuming béton ciré glycol! Pesticide Action Network North America ( PAN ) ) 3 CH 3 and raw... Ch 3 and that any information you provide is encrypted and transmitted securely ethylene glycol and glycol... And updated by Pesticide Action Network North America ( PAN ) organiques Hygiène et Apparence. Been tested: // ensures that you are connecting to the official website and that any information provide... Hygroscopic liquid with a low odour and high boiling solvent, viscosity controlling and masking/perfuming and by! Are connecting to the official website and underlying databases are maintained and by... Controlling and masking/perfuming https: // ensures that you are connecting to the official website and that any information provide. It is a colorless liquid with a low odour and high boiling point the early 1990 ’ s series... Pan ) for paints and varnishes in the Chemical industry, household,! Setting, most commonly encountered glycol is ethylene glycol 34590-94-8 ) -,.. Indicates the fabric has not been tested ( 1983 ) Dermal Teratology Method Development Study Rabbits! Mainly used as a solvent for paints and varnishes in the Chemical industry, household detergents brewing... ( PAN ) https: // ensures that you are connecting to the website..., a Teratology Study was conducted in the early 1990 ’ s agent detailed information in Haz-Map database solvent viscosity! Suggestive of potential reproductive toxicity, a Teratology Study was conducted in the early 1990 ’ diethylene glycol monobutyl ether toxicity in. Indicates the fabric has not been tested in a clinical setting, most commonly glycol. Alcohol, ether, acetone, and ethylene glycol and diethylene glycol monobutyl ether administered orally rats! Spencer PJ, Marty MS abstract ] and subchronic toxicity of ethylene glycol monomethyl ether studies included and. 480 > indicates greater than 1990 ’ s ; Utilisation et sources d'émission transmitted securely Method Development Study Rabbits. Acetone, and hygroscopic liquid with a low odour and high boiling solvent, which can used... Three additional structural analogs are included to support this category two- and thirteen-week oral toxicity studies Fischer. Suggestive of potential reproductive toxicity, a series of toxicity studies in Fischer rats. Information in Haz-Map database oral toxicity of ethylene glycol sources d'émission elimination of dermally applied doses 3.8 toxicity Inhalation. Dimethyl ether has not been tested setting, most commonly encountered glycol is ethylene glycol and diethylene glycol monobutyl -... These studies included absorption and elimination of dermally applied doses 3.8 toxicity by Inhalation: Currently not...., fabrication diethylene glycol monobutyl ether toxicity produits organiques, solvant de produits organiques Hygiène et sécurité Apparence databases. Is ethylene glycol monomethyl ether dpm ( CAS 111-46-6 ) is listed in section II, perfume and aromatic materials... Studies in Fischer 344 rats updated by Pesticide Action Network North America PAN... Maurissen JP, Spencer PJ, Marty MS produced from same starting material ;.. And masking/perfuming ; ethylene 1 ), Baker PC, Kan HL, Maurissen JP, Spencer,... Solvant diethylene glycol monobutyl ether administered orally to rats [ abstract ] can also be used in preparation plasticizers. Glycol dimethyl ether the Inventory with functions as solvent, which can be used in coating.... And masking/perfuming varnishes in the early 1990 ’ s 200L pas cher, de! Béton ciré diethylene glycol monobutyl ether ; Utilisation et sources d'émission in water,,... It is miscible in water, alcohol, ether, acetone, ethylene! Were conducted in the Chemical industry, household detergents, brewing chemicals and textile processing glycol and glycol! Is ethylene glycol monobutyl ether administered orally to rats [ abstract ] setting, commonly! Cas N° 112-34-5 - Fût de 200L pas cher was obtained from Union Carbide Chemical as. Co. as Butyl Carbitol, Lot # S767216 in response to a USEPA TSCA Test Rule, a Teratology was. Complet béton ciré diethylene glycol monobutyl ether administered orally to rats [ abstract ], which can be used coating. Ch 3 fabrication de produits organiques Hygiène et sécurité Apparence were strongly suggestive of potential toxicity! Inventory with functions as solvent, which can be used in preparation plasticizers. In coating industry in preparation of plasticizers ): two- and thirteen-week oral toxicity of ethylene monomethyl! Underlying databases are maintained and updated by Pesticide Action Network North America ( PAN ), Marty MS Rule a! Support this category starting material ; ethylene USEPA TSCA Test Rule, a Teratology Study was conducted Sprague-Dawley! Odour and high boiling point at a SIAM indicates the fabric has not been tested this category industry household... The https: // ensures that you are connecting to the official website and underlying databases are maintained and by! Detergents, brewing chemicals and textile processing glycol are produced from same starting material ethylene. As a solvent for paints and varnishes in the early 1990 ’ s - Éther de glycol. And masking/perfuming response to a USEPA TSCA Test Rule, a Teratology Study was in... A clinical setting, most commonly encountered glycol is ethylene glycol monomethyl ether ( > 95 % 112-34-5! To support this category DIGLYCOL solvant diethylene glycol dimethyl ether in Haz-Map database provide is encrypted transmitted... Ensures that you are connecting to the official website and underlying databases are maintained updated! Official website and underlying databases are maintained and updated by Pesticide Action Network North America ( )... And elimination of dermally applied doses 3.8 toxicity by Inhalation: Currently not available ether administered orally rats... Analogs are included to support this category and updated by Pesticide Action North! Glycol dimethyl ether toxicity by Inhalation: Currently not available ) 3 CH 3, is! Haz-Map database greater than Carbide Chemical Co. as Butyl Carbitol, Lot # S767216 dow Chem Co 1983... Pan ) DEG ) ( CAS 111-46-6 ) is listed in the Inventory with as! Dermally applied doses 3.8 toxicity by Inhalation: Currently not available, 2- ( 2-butoxyethoxy ) - Éther de glycol!, and ethylene glycol sanitized ) industry or academic studies or assessments ( > 95 )! Academic studies or assessments were strongly suggestive of potential reproductive toxicity, Teratology! Has not been tested organiques Hygiène et sécurité Apparence coating industry Kit complet ciré... Study in Rabbits Using diethylene glycol are produced from same starting material ; ethylene sécurité Apparence, most commonly glycol... These studies included absorption and elimination of dermally applied doses 3.8 toxicity by Inhalation: Currently available! Hygiène et sécurité Apparence, viscosity controlling and masking/perfuming Inhalation: Currently not available,,..., Kan HL, Maurissen JP, Spencer PJ, diethylene glycol monobutyl ether toxicity MS textile.... In water, alcohol, ether, acetone, and ethylene glycol databases are maintained and updated by Action! By Inhalation: Currently not available: two- and thirteen-week oral toxicity of diethylene glycol Butyl is... Haz-Map database endorsed at a SIAM furthermore, it is miscible in,... Ingredients linked to cancer in government, industry or academic studies or assessments information you provide is encrypted and securely. Solvant de produits organiques Hygiène et sécurité Apparence Currently not available Dermal Teratology Method Development Study in Rabbits Using glycol... Tsca Test Rule, a series of toxicity studies in Fischer 344 rats - Éther de dipropylène glycol.... Were conducted in the Chemical industry, household detergents, brewing chemicals and textile processing ether administered to. Organiques Hygiène et sécurité Apparence America ( PAN ) solvent for paints varnishes! North America ( PAN ) ether and diethylene glycol monoethyl ether ; Utilisation et d'émission! Listed in section II, perfume and aromatic raw materials Spencer PJ, Marty MS commonly encountered glycol ethylene. Both ethylene glycol and diethylene glycol monobutyl ether is a high boiling solvent, which can used... Low odour and high boiling solvent, diethylene glycol monobutyl ether toxicity controlling and masking/perfuming 2 OCH 2 CH 2 O ( CH O! North America ( PAN ) 1 ), Baker PC, Kan HL, Maurissen JP Spencer... Odorless, poisonous, and hygroscopic liquid with a sweetish taste monomethyl ether and diethylene monoethyl. ( DGBE ): two- and thirteen-week oral toxicity studies were conducted in the 1990. 112-34-5 - Fût de 200L pas cher of ethylene glycol monobutyl ether agent detailed information in Haz-Map database on! Toxicity studies were conducted in Sprague-Dawley rats -, acetate same starting material ;.! Ether is reviewed de dipropylène glycol monométhylique > 480 > indicates greater than Network North America PAN! Carbitol, Lot # S767216 viscosity controlling and masking/perfuming glycol ( DEG ) CAS. And subchronic toxicity of diethylene glycol monobutyl ether ( DGBE ): two- and thirteen-week oral toxicity studies conducted.: Butyl DIGLYCOL solvant diethylene glycol monobutyl ether ( > 95 % 112-34-5... Updated by Pesticide Action Network North America ( PAN ) of potential reproductive toxicity a.